ROBERT H. WATERSTON, KERSTIN LINDBLAD-TOH, EWAN BIRNEY, JANE ROGERS, JOSEP F. ABRIL, PANKAJ AGARWAL, RICHA AGARWALA, RACHEL AINSCOUGH, MARINA ALEXANDERSSON, PETER AN, STYLIANOS E. ANTONARAKIS, JOHN ATTWOOD, ROBERT BAERTSCH, JONATHON BAILEY, KAREN BARLOW, STEPHAN BECK, ERIC BERRY, BRUCE BIRREN, TOBY BLOOM, PEER BORK, MARC BOTCHERBY, NICOLAS BRAY, MICHAEL R. BRENT, DANIEL G. BROWN, STEPHEN D. BROWN, CAROL BULT, JOHN BURTON, JONATHAN BUTLER, ROBERT D. CAMPBELL, PIERO CARNINCI, SIMON CAWLEY, FRANCESCA CHIAROMONTE, ASIF T. CHINWALLA, DEANNA M. CHURCH, MICHELE CLAMP, CHRISTOPHER CLEE, FRANCIS S. COLLINS, LISA L. COOK, RICHARD R. COPLEY, ALAN COULSON, OLIVIER COURONNE, JAMES CUFF, VAL CURWEN, TIM CUTTS, MARK DALY, ROBERT DAVID, JOY DAVIES, KIMBERLY D. DELEHAUNTY, JUSTIN DERI, EMMANOUIL T. DERMITZAKIS, COLIN DEWEY, NICHOLAS J. DICKENS, MARK DIEKHANS, SHEILA DODGE, INNA DUBCHAK, DIANE M. DUNN, SEAN R. EDDY, LAURA ELNITSKI, RICHARD D. EMES, PALLAVI ESWARA, EDUARDO EYRAS, ADAM FELSENFELD, GINGER A. FEWELL, PAUL FLICEK, KAREN FOLEY, WAYNE N. FRANKEL, LUCINDA A. FULTON, ROBERT S. FULTON, TERRENCE S. FUREY, DIANE GAGE, RICHARD A. GIBBS, GUSTAVO GLUSMAN, SANTE GNERRE, NICK GOLDMAN, LEO GOODSTADT, DARREN GRAFHAM, TINA A. GRAVES, ERIC D. GREEN, SIMON GREGORY, RODERIC GUIGÓ, MARK GUYER, ROSS C. HARDISON, DAVID HAUSSLER, YOSHIHIDE HAYASHIZAKI, LADEANA W. HILLIER, ANGELA HINRICHS, WRATKO HLAVINA, TIMOTHY HOLZER, FAN HSU, AXIN HUA, TIM HUBBARD, ADRIENNE HUNT, IAN JACKSON, DAVID B. JAFFE, L. STEVEN JOHNSON, MATTHEW JONES, THOMAS A. JONES, ANN JOY, MICHAEL KAMAL, ELINOR K. KARLSSON, DONNA KAROLCHIK, ARKADIUSZ KASPRZYK, JUN KAWAI, EVAN KEIBLER, CRISTYN KELLS, W. JAMES KENT, ANDREW KIRBY, DIANA L. KOLBE, IAN KORF, RAJU S. KUCHERLAPATI, EDWARD J. KULBOKAS III, DAVID KULP, TOM LANDERS, J. P. LEGER, STEVEN LEONARD, IVICA LETUNIC, ROSIE LEVINE, JIA LI, MING LI, CHRISTINE LLOYD, SUSAN LUCAS, BIN MA, DONNA R. MAGLOTT, ELAINE R. MARDIS, LUCY MATTHEWS, EVAN MAUCELI, JOHN H. MAYER, MEGAN MCCARTHY, W. RICHARD MCCOMBIE, STUART MCLAREN, KIRSTEN MCLAY, JOHN D. MCPHERSON, JIM MELDRIM, BEVERLEY MEREDITH, JILL P. MESIROV, WEBB MILLER, TRACIE L. MINER, EMMANUEL MONGIN, KATE T. MONTGOMERY, MICHAEL MORGAN, RICHARD MOTT, JAMES C. MULLIKIN, DONNA M. MUZNY, WILLIAM E. NASH, JOANNE O. NELSON, MICHAEL N. NHAN, ROBERT NICOL, ZEMIN NING, CHAD NUSBAUM, MICHAEL J. O&Apos;CONNOR, YASUSHI OKAZAKI, KAREN OLIVER, EMMA OVERTON-LARTY, LIOR PACHTER, GENÍS PARRA, KYMBERLIE H. PEPIN, JANE PETERSON, PAVEL PEVZNER, ROBERT PLUMB, CRAIG S. POHL, ALEX POLIAKOV, TRACY C. PONCE, CHRIS P. PONTING, SIMON POTTER, MICHAEL QUAIL, ALEXANDRE REYMOND, BRUCE A. ROE, KRISHNA M. ROSKIN, EDWARD M. RUBIN, ALISTAIR G. RUST, RALPH SANTOS, VICTOR SAPOJNIKOV, BRIAN SCHULTZ, JÖRG SCHULTZ, MATTHIAS S. SCHWARTZ, SCOTT SCHWARTZ, CAROL SCOTT, STEVEN SEAMAN, STEVE SEARLE, TED SHARPE, ANDREW SHERIDAN, RATNA SHOWNKEEN, SARAH SIMS, JONATHAN B. SINGER, GUY SLATER, ARIAN SMIT, DOUGLAS R. SMITH, BRIAN SPENCER, ARNE STABENAU, NICOLE STANGE-THOMANN, CHARLES SUGNET, MIKITA SUYAMA, GLENN TESLER, JOHANNA THOMPSON, DAVID TORRENTS, EVANNE TREVASKIS, JOHN TROMP, CATHERINE UCLA, ABEL URETA-VIDAL, JADE P. VINSON, ANDREW C. VON NIEDERHAUSERN, CLAIRE M. WADE, MELANIE WALL, RYAN J. WEBER, ROBERT B. WEISS, MICHAEL C. WENDL, ANTHONY P. WEST, KRIS WETTERSTRAND, RAYMOND WHEELER, SIMON WHELAN, JAMEY WIERZBOWSKI, DAVID WILLEY, SOPHIE WILLIAMS, RICHARD K. WILSON, EITAN WINTER, KIM C. WORLEY, DUDLEY WYMAN, SHAN YANG, SHIAW-PYNG YANG, EVGENY M. ZDOBNOV, MICHAEL C. ZODY & ERIC S. LANDER


This authors list includes Stylianos E. Antonarakis, Emmanouil T. Dermitzakis, Alexandre Reymond, and Catherine Ucla


Of the Division of Medical Genetics, University of Geneva Medical School and University Hospital of Geneva, Geneva, Switzerland


The roughly 3 billion nucleotides of the human genome include the blueprints for all RNAs and proteins, the regulatory elements that ensure proper expression of all genes, the structural elements that govern chromosome function, and rich records of our evolutionary history. Some of these features can be easily recognized in the human sequence, but many are subtle and difficult to discern. One of the most powerful general approaches for unlocking the secrets of the human genome is comparative genomics. And a powerful and practical starting point for comparison is the laboratory mouse, Mus musculus. We report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome and an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences.


The study, which was supported financially in Switzerland by the Swiss National Science Foundation, the NCCR Frontiers in Genetics, the Swiss cancer League and the J. Lejeune and Childcare Foundations, is published in the December 5th, 2002 issue of the prestigious international journal Nature (Vol: 420, pages 520-562, 2002). To download the pdf version of the paper.


A description of our contribution to this work is provided here, as well as in the press release of our collaborators at MIT.