This page contains information supplementary to the following article submitted for publication to Genomics :


Refined localization of autosomal recessive non-syndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure and exclusion of six known genes in the region

 

Asher Berry1, Hamish S. Scott2#, Jun Kudoh3, Ilana Talior1, Michael Korostichevsky1, Marie Wattenhofer2, Michel Guipponi2, Christine Barras2, Colette Rossier2, Kazunori Shibuya3, Jun Wang3, Kazuhiko Kawasaki3, Shuichi Asakawa3, Shinsei Minoshima3, Nobuyoshi Shimizu3, Stylianos Antonarakis2, Batsheva Bonné-Tamir1

1 Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University, 69978 Ramat-Aviv, Israel.
2 Division of Medical Genetics, University of Geneva Medical School and Cantonal Hospital of Geneva, 1211 Geneva 4, Switzerland.
3 Department of Molecular Biology, Keio University School of Medicine, Shinanomachi, Shinjuku-ku, Tokyo 160-8552, Japan.
# Current address: Genetics and Bioinformatics Group, Walter and Eliza Hall Institute, Royal Parade, Parkville, P.O. Royal Melbourne Hospital, Victoria 3050, Australia.

Address for correspondence:

Batsheva Bonné-Tamir
Department of Human Genetics and Molecular Medicine,
Sackler School of Medicine,
Tel-Aviv University,
69978 Ramat-Aviv,
Israel
Phone 972-3-640-9318
Fax 972-3-640-9900
Email: bonne@post.tau.ac.il


GenBank/EMBL accession numbers of the cDNAs and genomic sequences of candidate genes are as follows; White (ABCG1), cDNA, X91249, genomic, AB038161; TFF3, cDNA, L08044; TFF2, cDNA, X51698; TFF1, cDNA, X00474; TFF gene cluster AB038162; PDE9A, cDNA, AF067223, genomic, AB017602; NDUFV3, cDNA derived from X99726/ 7/ 8, genomic AB038163.

Short running title: Refined localization of DFNB10 to < 1 Mb on 21q22.3

 

A BAC/cosmid contig spanning MX1-D21S171 (http://www.dmb.med.keio.ac.jp/seqpub/map/APECED.html)

 

Table 1. Primers for new microsatellite markers in 21q22.3

Table 2. Primers used for mutations analysis of the 6 known genes in the DFNB10 critical region



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