List of the 330 TAG s with statistically significant differences in occurrence between normal and Ts65Dn male brain SAGE libraries.
For each TAG (Tag Sequence) the number of its copies in Ts65Dn library (Ts65Dn) and normal library (Normals) together with the estimated p value and GenBank match (GBmatch) are shown.

TAG Sequence Ts65Dn Normal p value GB match
TCCCCGCACA 2 26 0.0000  
AAATTATTGG 110 59 0.0000 proteolipid protein (myelin)
GCCCCCCTCT 104 54 0.0000  
TCCCCGACAT 9 38 0.0000  
TTGGTGAAGG 19 52 0.0001 prothymosin beta 4
GACTGAATCT 12 39 0.0001 multiple matches
CGCCCGCCCG 65 30 0.0002 Notch2-like
ATTTTCGAGG 34 10 0.0002 ATPase, Na+/K+ transporting, beta 1 polypeptide
AATTCGCGGA 86 144 0.0002 transthyretin
TCCCCGTACG 8 31 0.0002  
GAAAGTTGGC 95 53 0.0002 apolipoprotein D
TCTCCAGGCG 38 77 0.0003 clusterin
CTGCTATCCG 9 32 0.0003 ribosomal protein L5, 3'end
AACGGGAGGT 48 20 0.0003 Scgn10 like-protein
CAGCTCTGCC 70 119 0.0004 ESTs, Weakly similar to NEUROGRANIN [Rattus norvegicus]
GACAACGCCA 17 44 0.0004 ESTs, Highly similar to ATP SYNTHASE GAMMA CHAIN, MITOCHONDRIAL [Rattus norvegicus]
GTGACCTGGC 169 115 0.0004 prostaglandin D2 synthase (21 kDa, brain)
AGGACAAATA 102 62 0.0007 biotinidase
TCCCCGTAAT 2 16 0.0007  
CGCGCTCTCT 29 9 0.0008  
CTGCTGGTGG 30 10 0.0009 GTP binding protein associated protein 1
GCCATCCCGG 13 1 0.0009  
CAGGTGAGCC 15 2 0.0010  
CGCAGTCCCC 0 10 0.0010  
TCGGCGTGGA 0 10 0.0010  
GTTGCTGAGA 17 41 0.0014 DNA segment, Chr X, human DXS648E
GACGGCTAAA 2 15 0.0015  
TCCCCCGTAC 2 15 0.0015  
TTTTGAGTGA 12 1 0.0016  
GCGCCAGCTC 118 78 0.0016 ubiquitin carboxy-terminal hydrolase L1
AAACGAAAGT 22 6 0.0017 ESTs, Highly similar to S-ADENOSYLMETHIONINE SYNTHETASE GAMMA FORM [Rattus norvegicus]
GCGGGCACCA 20 5 0.0017 ESTs
ACAGGAAGGA 1 12 0.0018  
ACTTCGTCCA 0 9 0.0019  
GAGTCACTCT 0 9 0.0019 ESTs
GCGGGTCGCC 16 3 0.0020  
GGGACCTAGG 23 7 0.0023 neuron specific gene family member 2
GTCTGGGGGG 2 14 0.0024 monoglyceride lipase
GCTATGAGAA 26 9 0.0024 amyloid beta (A4) precursor-like protein 1
CCCAGATATT 19 5 0.0028 tubulin, beta 4
GTGGCAGGCG 11 1 0.0029  
GTGTGCCCCC 11 1 0.0029 ESTs, Highly similar to HYPOTHETICAL 67.8 KD PROTEIN IN GND1-ERG9 INTERGENIC REGION [Saccharomyces cerevisiae]
GCTTTTGGGA 13 2 0.0034  
TGTAGTGTAA 8 0 0.0035 ribosomal protein S8
CCGCCTGTGG 14 34 0.0036 synapsin I
TCCCCGTGCA 2 13 0.0039  
TCTGGTCCGG 1 11 0.0041 flotillin 2
GCAGAGTGCG 32 14 0.0044 multiple matches
CCGCCGTGGG 0 8 0.0044 microtubule-associated protein 7
GTTGTGATTT 0 8 0.0044 Ewing sarcoma homolog
TGAGCACTCC 0 8 0.0044 follistatin-like
CCTTACCGCT 30 56 0.0046 ESTs
TCCGTGGTTG 28 53 0.0049 ESTs, Moderately similar to BIOTIN CARBOXYLASE [Anabaena pcc7120]
TTCTGGCCTG 10 27 0.0050 ESTs, Highly similar to EST00098 protein [H.sapiens]
GAGAGAAGAG 10 1 0.0051 microtubule-associated protein tau
GGGCAGGGAG 10 1 0.0051 ESTs
GTTTGCTGTG 16 4 0.0053 cathepsin B
GCGGGTTCGC 12 2 0.0062  
TGGTGCACGT 12 2 0.0062 ESTs, Weakly similar to similar to kinensin-like protein [C.elegans]
ATGAATTTTG 1 10 0.0065 ESTs, Highly similar to CELL DIVISION CONTROL PROTEIN 4 [Saccharomyces cerevisiae]
CCATTGATCA 1 10 0.0065 ESTs, Highly similar to bithoraxoid-like protein [R.norvegicus]
CGGATAACCA 1 10 0.0065 proliferation-associated protein 1
GCTTGTGACG 1 10 0.0065 transaldolase 1
TTACAGCAGA 1 10 0.0065 ESTs, Weakly similar to ORF YGL231c [S.cerevisiae]
TGCAGTCCCC 2 12 0.0065  
CCCCAGCCAG 25 48 0.0065 ribosomal protein S3
ATTGCTTAGA 7 0 0.0070 RNA binding motif protein 3
CAGTAACTTC 7 0 0.0070 aquaporin 4
CCCCGCCGCG 7 0 0.0070 zinc finger protein, multitype 1
CCCCTCCCCA 7 0 0.0070  
GGCCTTTGTG 7 0 0.0070 ESTs, Weakly similar to coded for by C. elegans cDNA CEESW58F [C.elegans]
GGATACGTTT 17 5 0.0075 ESTs
GGCGGGGCCC 17 5 0.0075 ESTs, Weakly similar to 230k bullous pemphigoid antigen BPM1 [M.musculus]
AATCACTGGC 0 7 0.0082 ESTs, Moderately similar to protein DS 1, 24K [H.sapiens]
CGACCCCGGG 0 7 0.0082  
CTAACCTCCA 0 7 0.0082  
GTGTTGTCGG 0 7 0.0082 ESTs, Weakly similar to S1-1 protein [R.norvegicus]
TAAGCAGGAC 0 7 0.0082  
CGCTGGTTCC 35 60 0.0087 replication factor C, 140 kDa
AACTGCACAC 13 3 0.0096 ESTs, Highly similar to SUCCINATE DEHYDROGENASE [Homo sapiens]
GGGTCCTGCT 8 22 0.0097 ESTs
CGCGGCAGGC 38 20 0.0104 dynactin 1
CAGGACTCCG 63 40 0.0106 stearoyl-Coenzyme A desaturase 2
CTCTTCCCCC 42 23 0.0110 phosphatidylethanolamine binding protein mRNA, complete cds
TCCCCGTACT 4 15 0.0111  
ACCAAGATCT 3 13 0.0112 ribosomal protein S19
ATGGGTCATC 3 13 0.0112 ESTs, Highly similar to TRANSLOCATION PROTEIN SEC62 [Saccharomyces cerevisiae]
TCTGCCCTCC 3 13 0.0112  
GATTCCGTGA 39 64 0.0113 ESTs, Highly similar to 60S RIBOSOMAL PROTEIN L37 [Homo sapiens; Rattus norvegicus]
GCCAAAAAAA 1 9 0.0113 ESTs, Highly similar to 2-OXOGLUTARATE DEHYDROGENASE E1 COMPONENT PRECURSOR [Homo sapiens]
GGCTTTGGAG 1 9 0.0113 ESTs, Moderately similar to HSPC005 [H.sapiens]
ACTCGGAGCC 23 43 0.0114 calmodulin
CAAACTGAAG 2 11 0.0114 ESTs, Highly similar to spliceosomal protein SAP 155 [H.sapiens]
CACTACACGG 2 11 0.0114 FK506 binding protein 2 (13 kDa)
GGGGCTCAGC 31 15 0.0115 glucose phosphate isomerase 1 complex
GTACTGACAT 9 23 0.0116  
GCAGCATCTG 16 5 0.0118 ESTs
CTGGCAGAAG 11 2 0.0125 ESTs, Highly similar to NIFU PROTEIN [Anabaena pcc7120]
TCTGGAGACA 11 2 0.0125  
AGAGCTGTGG 14 4 0.0132 NADH dehydrogenase flavoprotein 1
GTGTGTGGTG 19 7 0.0134 ESTs
TGAGAACTGC 19 7 0.0134 tetratricopeptide repeat domain
TCAGGCTGCC 153 199 0.0135 ferritin heavy chain
GTGTGCCGCT 17 6 0.0144  
AAGCTCAGTT 5 16 0.0146 ESTs
CCACAGAGCT 5 16 0.0146 Ena-vasodilator stimulated phosphoprotein
AAAGTTCGGA 6 0 0.0147 sid23p
AAGCCACAGA 6 0 0.0147 ESTs, Moderately similar to PUTATIVE SURFACE GLYCOPROTEIN C21ORF1 PRECURSOR [H.sapiens]
AGCAGCCCCT 6 0 0.0147  
CACTGGGTTG 6 0 0.0147 ESTs, Highly similar to unknown [H.sapiens]
CGGACGGCTT 6 0 0.0147  
GGGATTCCAG 6 0 0.0147  
GGTTCTGCCC 6 0 0.0147 ESTs
TAGTGGCGTA 6 0 0.0147 alpha internexin neuronal intermediate filament protein
TGAGCCTGGT 6 0 0.0147 latent transforming growth factor beta binding protein 3
TGGAGAACTA 6 0 0.0147 ESTs
TGGCCAAGCC 6 0 0.0147 polyhomeotic (mPh2) mRNA
TGTTCTTCCC 6 0 0.0147  
TTTGTGACTG 6 0 0.0147 C-terminal binding protein 1
GCCTTTATGA 12 27 0.0155 ribosomal protein S24
TCCGGGCGAG 12 3 0.0163 replication-dependent histone H2A.1 gene
GAACTTGCAA 18 7 0.0175 ESTs, Moderately similar to FARNESYL PYROPHOSPHATE SYNTHETASE [R.norvegicus]
CGTCTGTGAA 10 2 0.0175  
GGCCCCAAAC 10 2 0.0175 v-crk-associated tyrosine kinase substrate
AACGTTGGAA 0 6 0.0183 ESTs, Weakly similar to cytosolic inorganic pyrophosphatase [H.sapiens]
AACTTGGCTG 0 6 0.0183 guanylate kinase membrane-associated inverted 1
AAGCTGCCCT 0 6 0.0183 ORNITHINE AMINOTRANSFERASE PRECURSOR
AGCCCATCAA 0 6 0.0183 ESTs
AGGAGGGGTA 0 6 0.0183 RAB24, member RAS oncogene family
ATTCTGGCAG 0 6 0.0183 ESTs, Highly similar to UBIQUITIN-CONJUGATING ENZYME E2-17 KD 3 [Homo sapiens; Rattus norvegicus]
CCGAATTACC 0 6 0.0183 cornichon homolog (Drosophila)
CCTGTAATCC 0 6 0.0183 ESTs
CGGCCTACGT 0 6 0.0183 superoxide dismutase 2, mitochondrial
GGCAGACTGT 0 6 0.0183 EST
GGGATCCAGG 0 6 0.0183 ESTs, Weakly similar to coded for by C. elegans cDNA yk157f8.5 [C.elegans]
GGTAAAGTTA 0 6 0.0183 ESTs, Weakly similar to MITOCHONDRIAL ELONGATION FACTOR TS PRECURSOR [H.sapiens]
GTCCTTTTTC 0 6 0.0183 ESTs, Highly similar to ring-box protein 1 [M.musculus]
GTGGGGCGGG 0 6 0.0183 ESTs
TAACAAAGGA 0 6 0.0183 ESTs
TACCCCGTAC 0 6 0.0183  
TCCCCGTATA 0 6 0.0183  
TCTGGCAAAG 0 6 0.0183 EST
GCACCGAACA 28 14 0.0190 sid23p
GAAGATGAGC 36 20 0.0192 RAB3A, member RAS oncogene family
CAAAAATAAA 25 12 0.0197 ESTs
GAGATGCCTG 10 23 0.0205 ESTs, Highly similar to NADH-UBIQUINONE OXIDOREDUCTASE 42 KD SUBUNIT PRECURSOR [Bos taurus]
ACGTCGTGCG 8 1 0.0206  
CCTTTCTGTC 8 1 0.0206  
CTTTGGGGAC 8 1 0.0206 ESTs, Highly similar to down syndrome candidate region 1 [H.sapiens]
GCAGGCTTCG 8 1 0.0206 ESTs, Weakly similar to HYPOTHETICAL 54.9 KD PROTEIN C02F5.7 IN CHROMOSOME III [Caenorhabditis elegans]
GCCTGCCCCG 8 1 0.0206 cdc37 homolog
GGGCCCCGGG 8 1 0.0206 multiple matches
AAGAGAACAC 2 10 0.0208  
GGAGAAGAGC 2 10 0.0208  
TACGGCTAAA 2 10 0.0208  
AGAAAAAAAA 3 12 0.0209 multiple matches
GAGTGCCTGT 3 12 0.0209 ESTs
ATGCAACTAC 13 27 0.0211 ESTs, Highly similar to CYTOCHROME C OXIDASE POLYPEPTIDE VIB [Bos taurus]
TGGGGTTTCC 44 27 0.0214 multiple matches
GGGAGCGGGC 22 10 0.0217 ESTs, Highly similar to HYPOTHETICAL 109.5 KD PROTEIN IN PPA1-DAP2 INTERGENIC REGION [Saccharomyces cerevisiae]
TAACAGTTGT 13 4 0.0219 calnexin
AGAGAGGCCA 1 8 0.0226 ESTs, Weakly similar to PROFILIN I [M.musculus]
AGGCATTGTC 1 8 0.0226 ESTs
CATCAGCCTC 1 8 0.0226 multiple matches
CCCAGGCTTG 1 8 0.0226 ESTs
GACTCTTTCT 1 8 0.0226 ESTs
GGCCTCTAAA 1 8 0.0226 ESTs
TGCTGGTGCG 1 8 0.0226 ESTs
GGCAGTCCCC 5 15 0.0228 ESTs
TTGGCTCACA 5 15 0.0228 ESTs
GAATTTTTAC 16 6 0.0253  
GGGCAAGCCA 17 7 0.0268 estrogen related receptor, alpha
TGGCTTTTCT 28 15 0.0277 multiple matches
ATCCTAGGTC 11 3 0.0277  
CAGACGGAAG 11 3 0.0277 ESTs
GGGAAAACTT 11 3 0.0277  
GTCGGCCGCC 11 3 0.0277 Mus musculus DNaseI precursor mRNA, complete cds
GGGATGGCCA 8 19 0.0287 ESTs
AATATGTGTG 6 16 0.0298 cytochrome c oxidase, subunit VIc
AACGCTGCCA 25 42 0.0299 macrophage migration inhibitory factor
AACGGCTAAC 5 0 0.0302  
AACTATTAAA 5 0 0.0302 ESTs
AAGAGAACCC 5 0 0.0302  
AAGCACTGTG 5 0 0.0302 ESTs
AAGTTGCATT 5 0 0.0302 NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 1
ACCTTGCCCT 5 0 0.0302 ESTs, Highly similar to TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR [Homo sapiens]
ACTCCCCAGA 5 0 0.0302  
CAAATCCTGT 5 0 0.0302  
CCAACAACTG 5 0 0.0302  
CCCAGGCTGA 5 0 0.0302 ESTs
CCCTTGAGTC 5 0 0.0302  
CCTTTCAAAA 5 0 0.0302 general transcription factor II I
CCTTTCAAAC 5 0 0.0302 ESTs, Highly similar to similar to nuclear domain 10 protein NDP52 [H.sapiens]
CTGCATTAAG 5 0 0.0302 ESTs, Highly similar to enoyl-CoA hydratase [H.sapiens]
CTTGCAATCT 5 0 0.0302 ESTs, Weakly similar to HORMONE SENSITIVE LIPASE [M.musculus]
CTTTGGGGGC 5 0 0.0302 ESTs
CTTTTCAGCA 5 0 0.0302  
GAAAGGTCAG 5 0 0.0302 ESTs
GAACAGGACC 5 0 0.0302 ESTs
GACAAAAAAA 5 0 0.0302 ESTs
GATAATGCAC 5 0 0.0302 NADH dehydrogenase (ubiquinone) Fe-S protein 4 (18 kDa)
GCACACACCC 5 0 0.0302 EST
GCCTGTCTTC 5 0 0.0302 ESTs
GGAATTTTTA 5 0 0.0302 ESTs
GGGGCTATCG 5 0 0.0302  
GGGGGCGCGC 5 0 0.0302  
GTGTAGACCA 5 0 0.0302 ESTs
TAGTGTTTTC 5 0 0.0302  
TCAAACTGCC 5 0 0.0302  
TCATCTTTAA 5 0 0.0302 calreticulin
TCCTCACGTG 5 0 0.0302 pyruvate dehydrogenase 2
TCTTTAATCC 5 0 0.0302 ESTs
TGACAGCTTG 5 0 0.0302 ESTs
TGAGCCAACT 5 0 0.0302 ESTs
TGAGTTACAG 5 0 0.0302 nucleosome assembly protein 1-like 2
TGTGAGGCTC 5 0 0.0302  
TTCAGCTCGA 33 19 0.0303 ribosomal protein S7
CCGCCAAGGG 9 2 0.0320 ESTs, Moderately similar to hTOM34p [H.sapiens]
GCAGGTCCCC 9 2 0.0320 ESTs
GGGCCCAACT 9 2 0.0320 EST
GGGGAGACGC 9 2 0.0320 fibroblast growth factor receptor 1
TGCAGTGCAC 9 2 0.0320 ESTs
CTGCGAGATT 25 13 0.0322 ESTs, Highly similar to NADH-UBIQUINONE DEHYDROGENASE 24 KD SUBUNIT PRECURSOR [Rattus norvegicus]
AGAACTTCAA 7 1 0.0327  
CAGGGCGAGA 7 1 0.0327 ESTs, Highly similar to hypothetical protein [H.sapiens]
CTGGGCTTGA 7 1 0.0327  
GCAAGAGAGA 7 1 0.0327 glutamine synthetase
GCCCTGGCCC 7 1 0.0327  
GGATCCCCAA 7 1 0.0327 ESTs
TCCAACTCCT 7 1 0.0327 ESTs, Weakly similar to weak similarity to Bacillus stearothermophilus 30S ribosomal protein S21 [C.elegans]
TGAACCCATT 7 1 0.0327 cytochrome c oxidase, subunit VI a, polypeptide 1
TGGAGGAGCT 7 1 0.0327 ESTs, Highly similar to formin binding protein 11 [M.musculus]
GAGACCATCG 3 11 0.0333 ESTs, Highly similar to (defline not available 6013323) [M.musculus]
GCGAGGAAGA 3 11 0.0333  
GGGGAAATCG 80 59 0.0341 ESTs, Moderately similar to THYMOSIN BETA-10 [Homo sapiens; Rattus norvegicus; Equus caballus]
CCAGGCCGGG 15 6 0.0347 protein kinase C, zeta
GAGCCCCTTG 15 6 0.0347  
TGGAATGCAG 15 6 0.0347 calnexin
AGTTGGAAAC 12 4 0.0356 nuclear factor of activated T-cells, cytoplasmic 2
CCCGTAGCCC 12 4 0.0356 tropomyosin 2, beta
GCGCCCTGAT 12 4 0.0356  
GGCACCATCT 12 4 0.0356  
TACCCCAGGG 12 4 0.0356  
TTGATCCCCA 12 4 0.0356 lysosomal membrane glycoprotein 1
GGGGCAGCCC 36 22 0.0357 cornichon (Drosophila)-like
GCACAACTTG 213 181 0.0361 calmodulin 2
CTACTGACAT 2 9 0.0364  
GCGAGGGAGC 2 9 0.0364 dim1 (S. pombe)
GGAGCGCTAT 2 9 0.0364 ESTs
AAACATTGGG 0 5 0.0366 ESTs, Weakly similar to Similar to S.cerevisiae EMP70 protein precursor [H.sapiens]
ACAACAAAAT 0 5 0.0366 ESTs
ACCCGCACCC 0 5 0.0366  
ACTCTTTCCT 0 5 0.0366 ESTs
ACTGTGTCTT 0 5 0.0366 ESTs
AGAGGCACTT 0 5 0.0366 ESTs, Highly similar to ACETYL-COENZYME A SYNTHETASE [Escherichia coli]
AGATGGCTTT 0 5 0.0366 mast cell growth factor
AGCCGTGTAT 0 5 0.0366 ESTs
AGGCTGGTGA 0 5 0.0366 proteasome (prosome, macropain) subunit, beta type 1
CAAATGGACT 0 5 0.0366 ESTs
CACAGCGTTG 0 5 0.0366  
CACTTTTTTT 0 5 0.0366  
CCAAGGCTGC 0 5 0.0366 ESTs
CGGGACCCCA 0 5 0.0366  
CTAGTCGCAA 0 5 0.0366 ESTs, Highly similar to THYMIDINE PHOSPHORYLASE [Homo sapiens]
CTGTGTAATT 0 5 0.0366 ESTs
GAAACCAGGA 0 5 0.0366 ESTs, Weakly similar to PLATELET-ENDOTHELIAL TETRASPAN ANTIGEN 3 [M.musculus]
GAATTGATGA 0 5 0.0366 secretogranin II
GATCTGACCC 0 5 0.0366 ESTs
GCCACGCCCT 0 5 0.0366  
GCTTAAAAAT 0 5 0.0366 ESTs
GGAAGTTGGC 0 5 0.0366  
GGGAAGAGAT 0 5 0.0366 ESTs
GGTACCCCCA 0 5 0.0366 ESTs
GTTTTCTAGT 0 5 0.0366 ESTs, Highly similar to PRE-MRNA SPLICING HELICASE BRR2 [Saccharomyces cerevisiae]
TAGACCAGGC 0 5 0.0366 ESTs, Weakly similar to VITAMIN K-DEPENDENT GAMMA-CARBOXYLASE [Homo sapiens]
TATGTCAAGT 0 5 0.0366  
TCCAGAAAAT 0 5 0.0366  
TCCCCGTTCA 0 5 0.0366  
TGAACTGTGT 0 5 0.0366 ESTs
TGGATGCTGG 0 5 0.0366 adenomatosis polyposis coli binding protein Eb1
TGGGCCACAC 0 5 0.0366 ESTs, Weakly similar to KIAA0990 protein [H.sapiens]
TTCCCCACGT 0 5 0.0366 cell division cycle 2 homolog (S. pombe)-like 2
CAATAAACTG 23 12 0.0367 suppressor of initiator codon mutations-Yeast homolog related sequence 1
GGCTGGGGGC 26 14 0.0369 profilin 1
ACCGGTATTT 5 14 0.0376 protein kinase C, beta
CCAATGCAGC 5 14 0.0376 ESTs, Highly similar to PROBABLE 3-OXOADIPATE COA-TRANSFERASE SUBUNIT B [Bacillus subtilis]
AAAGTGTTTC 1 7 0.0379 ESTs
ATCTCAAACC 1 7 0.0379 ESTs
CCTACAGTCC 1 7 0.0379  
CGCAATTCAA 1 7 0.0379  
GAGAAAGTTC 1 7 0.0379 ESTs
GGATGATGGT 1 7 0.0379 ESTs, Highly similar to EXTRACELLULAR RIBONUCLEASE LE PRECURSOR [Lycopersicon esculentum]
GTCAGGGGGA 1 7 0.0379 ESTs
TCCCCGTCCA 1 7 0.0379  
TCCCTACTAA 1 7 0.0379  
TGAGCAGTGG 1 7 0.0379  
TGTGTTCCCA 1 7 0.0379 ESTs, Weakly similar to (defline not available 5931573) [M.musculus]
GGATTTGGCT 45 66 0.0388 keratin complex 2, basic, gene 1
ATGAAACTTT 19 9 0.0393 ESTs
TCAGAGGCCT 22 37 0.0396 ESTs
AACAAAGCAA 10 3 0.0402 ESTs, Moderately similar to Unknown [H.sapiens]
AGGCCAGCTG 10 3 0.0402 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3 F
GCCAAATTTG 10 3 0.0402 ESTs, Highly similar to 26S proteasome subunit p112 [R.norvegicus]
GGGCTGGAAT 10 3 0.0402 ESTs
CTTGCAAGTG 13 25 0.0417 ESTs, Highly similar to NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT [Bos taurus]
GAGTTCTCTG 13 25 0.0417 ESTs, Moderately similar to HSPC035 protein [H.sapiens]
GCTCTGGCTG 8 18 0.0417 ESTs, Weakly similar to CGI-61 protein [H.sapiens]
GCTGGCAGCC 32 19 0.0417 RAD9 homolog (S. pombe)
TTGGCTGCCC 43 28 0.0422 ribosomal protein S14
GTCTGCTGAT 6 15 0.0439 guanine nucleotide binding protein, beta-2, related sequence 1
GAGGAGTGGG 9 19 0.0461  
CTTCTCATTT 3 10 0.0462 membrane transporter protein
GGCAATTCAA 3 10 0.0462  
TGTCGCCAGG 3 10 0.0462  
CCAGAACAGA 14 26 0.0464 ribosomal protein L30
GCCTGTGGTG 21 11 0.0469 lymphocyte antigen 6 complex, locus H
GGGTGCAGCC 25 14 0.0470 FK506 binding protein 8 (38 kDa)
GTGCCCTCCA 34 21 0.0475  
TGGAACCTTG 13 5 0.0478 ESTs
TTCTCCTCAG 13 5 0.0478 ESTs, Moderately similar to (defline not available 5815343) [M.musculus]
ACTGCCTGCT 17 30 0.0482 ESTs, Weakly similar to SH3 domain binding protein [R.norvegicus]
TATGCAACCC 33 21 0.0486 necdin
AAAACAGTGG 15 27 0.0489 ribosomal protein L37a
GGGAGGGAGG 17 8 0.0499  
AGCAGTCCCT 11 4 0.0502 homogentisate 1, 2-dioxygenase
CTCAGAAAGC 11 4 0.0502 ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa, isoform 2
GCTGCCTTCC 11 4 0.0502 Harvey rat sarcoma virus oncogene
TGAACCTGAG 11 4 0.0502 ESTs
CTCCTGCAGC 5 13 0.0508 sid478p
GACGAGATTC 5 13 0.0508 ESTs, Weakly similar to Lpe5p [S.cerevisiae]

List of TAGs corresponding to ribosomal protein genes with statistically significant differences between normal and Ts65Dn male brain SAGE libraries.
The identity for each TAG (Description) and statistical significance (p) of observed differences between normal and Ts65Dn SAGE libraries are presented. The number of TAGs in SAGE libraries derived from normal (Normal males) or Ts65Dn (Trisomics) mouse male brains, normal female brains (Normal females) and mouse embryonic cell line 3T3 are shown. TAGs from the 3T3 SAGE library were normalized for a total of 50,000.

Description TAG Normal Males Trisomic Males P Normal Females 3T3 (Nor50K)
ribosomal protein L26 TGGGCATCCA 41 12 0.0000 26 0
ribosomal protein L5 CTGCTATCCG 32 9 0.0003 19 40
ribosomal protein S8 TGTAGTGTAA 0 8 0.0035 6 12
ribosomal protein S6 GCAGAGTGCG 14 32 0.0044 19 85
ribosomal protein S3 CCCCAGCCAG 48 25 0.0065 42 156
ribosomal protein S19 ACCAAGATCT 13 3 0.0112 17 46
ESTs, Highly similar to 60S RIBOSOMAL PROTEIN L37 [Homo sapiens; Rattus norvegicus] GATTCCGTGA 64 39 0.0113 67 108
ribosomal protein S24 GCCTTTATGA 27 12 0.0155 30 43
ribosomal protein S7 TTCAGCTCGA 19 33 0.0303 38 44
ESTs, Weakly similar to Bacillus stearothermophilus 30S ribosomal protein S21 [C.elegans] TCCAACTCCT 1 7 0.0327 7 2
EST, Weakly similar to 60S ACIDIC RIBOSOMAL PROTEIN P2 [R.norvegicus] GGATTTGGCT 66 45 0.0388 78 44
ribosomal protein S14 TTGGCTGCCC 28 43 0.0422 40 73
ribosomal protein L30 CCAGAACAGA 26 14 0.0464 23 68
ribosomal protein L37a AAAACAGTGG 27 15 0.0489 35 36

List of known MMU16 genes present in three copies in Ts65Dn mice and their expression level as detected by the number of corresponding TAGs in normal and Ts65Dn SAGE library.
For each gene (Gene name, GenBank accession number: GB#) the corresponding most 3 TAG was used to determine the TAG frequency in SAGE libraries derived from normal or Ts65Dn mouse male brains. (attached as Table 5)

Gene name GB# pA-site TAG sequence Ts65Dn Normal
App X59379 yes ATAGCTTTCT 26 23
Grik1 X66118 yes GATAGAGGGA 0 0
Il10rb U53696 no AACATTTTGG 0 0
Sod1 M35725 yes AGAAACAAGA 7 10
Tiam1 U05245 yes ATGTGTCTAT 1 0
Cbfa2 D13802 yes CACAGACCCC 0 0
Mak-V AF055919 no AGTAAGGACT 0 1
Synp     No mouse homologue    
Rack17     No mouse homologue    
Ifnar2 AF013486 yes GAGAGCTACG 3 0
Ifngt1     No mouse homologue    
C21orf4     No mouse homologue    
Gart U01024 yes GCCAAACTGA 1 1
Son     No mouse homologue    
Itsn Esi1 AF132478 no GACCCCAGCC 0 0
Itsn Esi1L AF132481 no AGGTCCCCAC 0 0
Atpo     No mouse homologue    
Slc5a3     No mouse homologue    
Mirp1     No mouse homologue    
Kcnq1 U70068 yes TGCAGCCTGC 0 1
Dscr1     No mouse homologue    
Clic3     No mouse homologue    
Ifngr2 U69599 yes CCTTTATTCC 3 0
Cbr U31966 yes GTGAACCCAA 9 3
Sim2 D64135 yes TTGTGTGTAA 0 0
Ttc3-Tprd AB008516 yes CCTTACACTT 4 4
Dyrk1a U58497 no GTCGACGCGG 0 0
Kcnj6 U51122 yes TGTGAGATGC 0 0
Erg S66169 no GGCTCCTATC 0 0
Ets2 J04103 no CCATCCTGGG 0 2
Hmg14 X53476 yes TAATAAAAAT 1 0
Pcp4 X17320 yes AAGAGAAACC 46 39
Dscam     No mouse homologue    
Mx1 M12279 yes TGTTTGCTTC 1 0
Mx2 J03368 yes CTCCAGCTCC 0 0